Angiokeratoma corporis diffusum--a case report.

Angiokeratoma corporis diffusum, a rare clinical type of angiokeratoma, reported in association with various diseases of which Fabry disease is most common. Fabry disease, an X-linked recessive inborn error of glycosphingolipid metabolism due to deficiency of lysosomal enzyme αgalactosidase A . Clinically the disease is characterized by acroparesthesias, multiple cherry red coloured raised angiomatous hyperkeratotic lesions over trunk, abdomen, sides of buttocks and genitilia. A 27-year-old male born to a consanguineous marriage presents with acroparaesthesias and multiple cherry red and hyperkeratotic lesions over trunk, abdomen, sides of buttocks and genitilia. Histopathological examination is consistent with angiokeratoma and our case was diagnosed as angiokeratoma corporis diffusum. This case is being reported because of its rarity.